Do not use more of it and do not use it more often than your doctor ordered.
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Viagra can help you have an erection when sexual stimulation occurs.
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
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Viagra can cause mild, temporary lowering of your blood pressure.
Based upon measurements of sildenafil in semen of healthy volunteers 90 minutes after dosing, less than 0.
Presently, using them together is not recommended .
The changes from baseline in scoring on the two end point questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) were highly statistically significantly in favor of Viagra.
If you take Viagra with any nitrate medicine or recreational drug containing nitrates, your blood pressure could suddenly drop to an unsafe level.
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This is consistent with ritonavir's marked effects on a broad range of P450 substrates.
In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance.
The penis cannot fill with enough blood.
Read the directions carefully before using the medicine .
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.
Viagra is contraindicated in patients with a known hypersensitivity to any component of the tablet.
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In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.
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It is intended for use only by men who have a condition called erectile dysfunction.
Some of these side effects are more likely to occur with higher doses.
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Adverse Reactions CLINICAL TRIALS Viagra was administered to over 3700 patients (aged 19–87 years) during pre-marketing clinical trials worldwide.
If you experience sudden loss of vision in one or both eyes, stop using sildenafil and contact your doctor immediately.
Clinical Studies In clinical studies, Viagra was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity.
Viagra was effective in a broad range of ED patients, including those with a history of coronary artery disease, hypertension, other cardiac disease, peripheral vascular disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical prostatectomy, transurethral resection of the prostate (TURP) and spinal cord injury, and in patients taking antidepressants/antipsychotics and antihypertensives/diuretics.
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These effects are usually mild to moderate and usually don't last longer than a few hours.
Across all trials, Viagra improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo.
This medicine can help many men when it is used as prescribed by their doctors.
Older adults—Elderly people are especially sensitive to the effects of sildenafil, which may increase their chance of having side effects.
Permanent damage and impotence could result.
Erectile dysfunction was attributed to organic (58%; generally not characterized, but including diabetes and excluding spinal cord injury), psychogenic (17%), or mixed (24%) etiologies.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Following a review of the data from these first 4 subjects (details provided below), the Viagra dose was reduced to 25 mg.
This medicine usually begins to work within 30 minutes after taking it for erectile dysfunction.
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Of the twenty subjects who were ultimately assigned to treatment, a total of 13 subjects successfully completed dose period 1, and seven had successfully completed the previous doxazosin study (using Viagra 50 mg).
If you have questions about side effects, contact your health care provider.
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Its affects during pregnancy and breastfeeding have not been studied.
Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11).
Counseling of patients about the protective measures necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), may be considered.
The patient addressed both questions at the final visit for the last 4 weeks of the study.
Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra.
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Most studies assessed the efficacy of Viagra approximately 60 minutes post dose.
Hemic and Lymphatic: anemia and leukopenia.
Sixty-three percent, 74%, and 82% of the patients on 25 mg, 50 mg and 100 mg of Viagra, respectively, reported an improvement in their erections, compared to 24% on placebo.
Viagra will not prevent pregnancy.
Also use cautiously if you have a genital problem or deformity such as Peyronie's disease.
After sex is over, the erection goes away.
Therefore sexual activity may not be advisable for people who have heart problems.
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For the 17 subjects who received Viagra 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.
The possible categorical responses to these questions were (0) no attempted intercourse, (1) never or almost never, (2) a few times, (3) sometimes, (4) most times, and (5) almost always or always.
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This is the high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs.
Most, but not all, of these patients had underlying anatomic or vascular risk factors for developing NAION, including but not necessarily limited to: low cup to disc ratio ("crowded disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking.
Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes.
Your doctor will adjust the dosage if the drug is not working properly for you.
Be sure that any discarded medicine is out of the reach of children.
Hepatic Insufficiency In volunteers with hepatic cirrhosis (Child-Pugh A and B), sildenafil clearance was reduced, resulting in increases in AUC (85%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
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However, check with your doctor if any of the following side effects continue or are bothersome: More common Aches or pains in muscles; bloody nose; diarrhea; difficult or labored breathing; flushing; headache; nasal congestion; pain or tenderness around eyes and cheekbones; redness of skin; sneezing; stomach discomfort following meals; stuffy or runny nose; trouble in sleeping; unusually warm skin Rare Anxiety Note: The following rare side effects have not been completely established as being caused by sildenafil Abdominal pain; abnormal dreams; clumsiness or unsteadiness; cough; diarrhea or stomach cramps (severe or continuing); difficulty in swallowing; ear pain; increased amount of saliva; increased skin sensitivity; lack of coordination; loss of bladder control; mental depression; nausea; numbness or tingling of hands, legs, or feet; rectal bleeding; redness or irritation of the tongue; redness, soreness, swelling, or bleeding of gums; ringing or buzzing in ears; sensation of motion, usually whirling, ei
Physicians should advise patients to stop use of all PDE5 inhibitors, including Viagra, and seek medical attention in the event of a sudden loss of vision in one or both eyes.
Most, but not all, of these men had heart problems before taking this medicine.
Do not let anyone else take your Viagra.
If this is not treated right away, it could lead to permanent sexual problems such as impotence.
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It is especially important to check with your doctor before combining Viagra with the following: Viagra should not be used by women.
Older adults—Elderly people are especially sensitive to the effects of sildenafil, which may increase their chance of having side effects.
FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby.
It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient's underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors (see PRECAUTIONS/Information for Patients).
There was no impairment of fertility in rats given sildenafil up to 60 mg/kg/day for 36 days to females and 102 days to males, a dose producing an AUC value of more than 25 times the human male AUC.
In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events.
Viagra is contraindicated in patients with a known hypersensitivity to any component of the tablet.
Drug Interactions Effects of Other Drugs on Viagra In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route).
An extra patient leaflet is available with Viagra .
5 hour before sexual activity.
If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
You should call a doctor immediately if you ever have an erection that lasts more than 4 hours.
Percentage of Patients Reporting an Improvement in Erections.
It is not possible to determine whether these events are related directly to Viagra, to sexual activity, to the patient's underlying cardiovascular disease, to a combination of these factors, or to other factors (see WARNINGS for further important cardiovascular information).
Viagra does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS.
When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.
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Pharmacokinetics and Metabolism Viagra is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25–63%).
It is not known if Viagra is found in breast milk.
These side effects may go away during treatment as your body adjusts to the medicine.
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Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision.
Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, and unusual tiredness or weakness; bone pain; breast enlargement; chest pain; chills; confusion; convulsions (seizures); coughing up blood; deafness; decrease in amount of urine or in frequency of urination; dizziness or lightheadedness, especially when getting up from a lying or sitting position; dry eyes; dry mouth; dryness, redness, scaling, or peeling of the skin; eye pain; fainting or faintness; fast, irregular, or pounding heartbeat; feeling of something in the eye; groups of skin lesions with swelling; headache (severe or continuing); heart failure; hives; increase in size of pupil; increased sweating; increased thirst; itching of skin; low blood pressure; lower back or side pain; migraine headache; nausea (severe or continuing); nervousness; numbness of hands; painful, swollen joints; redness, itching, or tearing of eyes; shortness of breath or troubled breathing; skin paleness; skin rash; skin ulcers; sore throat and fever or