It is not known if sildenafil passes into breast milk or if it could harm a nursing baby.
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Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
Viagra was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated.
Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra.
If needed, your doctor may increase your daily dose to 100 mg or decrease your daily dose to 25 mg.
Viagra should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia).
Store away from heat, moisture, and light.
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Do not use other medicines or treatments for ED while you are taking Viagra .
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Do not use more of it and do not use it more often than your doctor ordered.
Musculoskeletal: arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis.
The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility.
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Therefore sexual activity may not be advisable for people who have heart problems.
Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking a PDE5 inhibitor.
Beginning in about 30 minutes and for up to 4 hours, Viagra can help you get an erection if you are sexually excited.
Carcinogenesis, Mutagenesis, Impairment of Fertility Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29- and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg.
Talk to your pharmacist if you have questions about this information.
Do not start or stop taking any medicines before checking with your doctor or pharmacist.
Most important fact about Viagra Viagra causes erections only during sexual excitement.
If you miss a dose of Viagra and you still intend to engage in sexual activity, take it as soon as you remember.
The penis cannot fill with enough blood.
Keep Viagra in its original container.
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Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems.
Less common Abnormal vision, including blurred vision, seeing shades of colors differently than before, or sensitivity to light; bladder pain; burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings; burning feeling in chest or stomach; cloudy or bloody urine; dizziness; increased frequency of urination; indigestion; pain on urination; stomach upset; tenderness in stomach area Rare Bleeding of the eye; convulsions (seizures); decreased vision or other changes in vision; double vision; prolonged, painful, or inappropriate erection of penis; redness, burning, or swelling of the eye; vision loss, temporary Note: The following rare side effects have not been completely established as being caused by sildenafil Blood sugar problems (more likely with patients with diabetes mellitus), such as anxiety, behavior change similar to drunkenness, blurred vision, cold sweats, confusion, cool and pale skin, difficulty in concentrating, drowsiness, excessive hunger, fast heartbeat, headache,
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You may also report side effects at http://www.
Precautions General The evaluation of erectile dysfunction should include a determination of potential underlying causes and the identification of appropriate treatment following a complete medical assessment.
The use of Viagra offers no protection against sexually transmitted diseases.
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In the second study, a single oral dose of Viagra 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH.
Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.
Based upon measurements of sildenafil in semen of healthy volunteers 90 minutes after dosing, less than 0.
Sildenafil was not carcinogenic when administered to mice for 18–21 months at dosages up to the Maximum Tolerated Dose (MTD) of 10 mg/kg/day, approximately 0.
The following events occurred in <2% of patients in controlled clinical trials; a causal relationship to Viagra is uncertain.
Your doctor may prescribe a lower dose of Viagra in certain circumstances.
Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men.
Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
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Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
Effects of Viagra on Other Drugs In vitro studies Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 µM).
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Viagra does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS.
Drug information contained herein may be time sensitive.
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Viagra demonstrated statistically significant improvement compared to placebo in all 21 studies.
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Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.
The mean times (adjusted for baseline) to onset of limiting angina were 423.
Treatment with doxazosin continued for at least 7 days after dose period 1.
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Digestive: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis.
Carcinogenesis, Mutagenesis, Impairment of Fertility Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29- and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg.
Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration.
The use of Viagra offers no protection against sexually transmitted diseases.
There were three subjects with a decrease from baseline in standing systolic BP >30mmHg following Viagra 25 mg, one subject with a decrease from baseline in standing systolic BP > 30 mmHg following placebo and two subjects with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra and placebo.
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Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
Presently, using them together is not recommended .
Viagra (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg).
If you are or will be breast-feeding while you use Viagra , check with your doctor.
Viagra may also be used for other purposes not listed in this medication guide.
Following at least 14 consecutive daily doses of doxazosin, Viagra 100 mg or matching placebo was administered simultaneously with doxazosin.
Follow your doctor's orders or the directions on the label .
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Analysis of the safety database showed no apparent difference in the side effect profile in patients taking Viagra with and without antihypertensive medication.
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In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 1 hour after administration of Viagra 50 mg and resolving after approximately 7.
Metabolism and Excretion Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes.
You will need to discuss the benefits and risks of using Viagra while you are pregnant.
The titration studies, in which most patients received 100 mg, showed similar results.
Pharmacodynamics Effects of Viagra on Erectile Response In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan®), after Viagra administration compared with placebo.
The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo.
If any develop or change in intensity, inform your doctor as soon as possible.
Across all trials, Viagra improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo.
Viagra is an oral drug for male impotence, also known as erectile dysfunction (ED).
Data from subjects exposed to high systemic levels of sildenafil are limited.
Pregnancy Category B No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits which received up to 200 mg/kg/day during organogenesis.
Viagra may also be used for other purposes not listed in this medication guide.
The primary endpoint was time to limiting angina in the evaluable cohort.
For the 20 subjects who received Viagra 100 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured after administration of Viagra at the same times as those specified for the previous doxazosin studies.
After the man is done having sex, this extra blood flows out of the penis back into the body.
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Use sildenafil exactly as directed by your doctor .
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Be equally cautious if you have severe high or low blood pressure, heart failure, or unstable angina (crushing heart pain that occurs at any time).
Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration.
Doses range from 25 milligrams to 100 milligrams, depending on the drug's effect.
While this normally would be expected to be of little consequence in most patients, prior to prescribing Viagra, physicians should carefully consider whether their patients with underlying cardiovascular disease could be affected adversely by such vasodilatory effects, especially in combination with sexual activity.
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One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period.
Viagra is used as needed, so you are not likely to be on a dosing schedule.
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If you take any medicines that contain nitrates – either regularly or as needed – you should never take Viagra.
Allow 24 hours to pass between doses.
Mothers who are taking this medicine for pulmonary arterial hypertension and who wish to breast-feed should discuss this with their doctor.
These doses represent, respectively, about 20 and 40 times the MRHD on a mg/m2 basis in a 50 kg subject.
If you have a bleeding disorder, a stomach ulcer, or the inherited eye condition known as retinitis pigmentosa, use Viagra with caution.
Hemic and Lymphatic: anemia and leukopenia.
Special Senses: diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal vascular disease or bleeding, vitreous detachment/traction, paramacular edema and epistaxis.
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Effects of Viagra on Blood Pressure Single oral doses of sildenafil (100 mg) administered to healthy volunteers produced decreases in sitting blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.
If you take Viagra after a high-fat meal (such as a cheeseburger and french fries), the medicine may take a little longer to start working.
Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision.
eatments that cause erections (eg, medicines injected or inserted into the penis, implants or vacuum pumps) Some MEDICINES MAY INTERACT with Viagra .
Viagra relaxes muscles and increases blood flow to particular areas of the body.
The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse.
Patients who are taking this medicine for pulmonary arterial hypertension may also need to be started at a lower dose.
Discuss any possible risks to your baby.
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There were three subjects with a decrease from baseline in standing systolic BP >30mmHg following Viagra 25 mg, one subject with a decrease from baseline in standing systolic BP > 30 mmHg following placebo and two subjects with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra and placebo.
Why should Viagra not be prescribed?
Viagra has systemic vasodilatory properties and may augment the blood pressure lowering effect of other anti-hypertensive medications.
Do not share it with other people.
One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted.
Two of these subjects had a standing SBP < 85mmHg.