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The safety and efficacy of combinations of Viagra with other treatments for erectile dysfunction have not been studied.
There are no adequate and well-controlled studies of sildenafil in pregnant women.
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In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance.
In humans, Viagra has no effect on bleeding time when taken alone or with aspirin.
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This includes nitroglycerin.
The following information includes only the average doses of sildenafil.
It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors.
Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors.
Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.
Doses range from 25 milligrams to 100 milligrams, depending on the drug's effect.
Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased.
Although not all of these side effects may occur, if they do occur they may need medical attention.
Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury.
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You may report side effects to FDA at 1-800-FDA-1088.
Viagra is not a hormone or an aphrodisiac.
Viagra is contraindicated in patients with a known hypersensitivity to any component of the tablet.
In the following patients: age >65, hepatic impairment (e.
If you have questions about side effects, contact your health care provider.
Mothers who are taking this medicine for pulmonary arterial hypertension and who wish to breast-feed should discuss this with their doctor.
Sixty-three percent, 74%, and 82% of the patients on 25 mg, 50 mg and 100 mg of Viagra, respectively, reported an improvement in their erections, compared to 24% on placebo.
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Viagra was effective in a broad range of ED patients, including those with a history of coronary artery disease, hypertension, other cardiac disease, peripheral vascular disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical prostatectomy, transurethral resection of the prostate (TURP) and spinal cord injury, and in patients taking antidepressants/antipsychotics and antihypertensives/diuretics.
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Treating erectile dysfunction (ED).
Viagra was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover).
A starting oral dose of 25 mg should be considered in those patients (see DOSAGE AND ADMINISTRATION).
A starting oral dose of 25 mg should be considered in those patients (see DOSAGE AND ADMINISTRATION).
In the third study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 3-period crossover design to 20 generally healthy males with BPH.
Before taking Viagra, tell your doctor if you are allergic to any drugs, or if you have If you have any of these conditions, you may need a dose adjustment or special tests to safely take Viagra.
It is not meant to take the place of your doctor's instructions.
Call your doctor for medical advice about side effects.
Physicians should advise patients of the potential for Viagra to augment the blood pressure lowering effect of alpha-blockers and anti-hypertensive medications.
This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see Pharmacodynamics).
It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil.
If Viagra gives you an allergic reaction, do not use it again.
Pregnancy, Nursing Mothers and Pediatric Use Viagra is not indicated for use in newborns, children, or women.
These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including Viagra.
The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo.
Two of these subjects had a standing SBP < 85mmHg.
A starting oral dose of 25 mg should be considered in those patients (see DOSAGE AND ADMINISTRATION).
The usual dose is 50 milligrams.
Heart attack, stroke, irregular heart beats, and death have been reported rarely in men taking Viagra.
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POST-MARKETING EXPERIENCE Cardiovascular and cerebrovascular Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of Viagra.
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Your doctor will adjust the dosage if the drug is not working properly for you.
Do not store in the bathroom, near the kitchen sink, or in other damp places.
Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Viagra.
Physicians should also discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye, including whether such individuals could be adversely affected by use of vasodilators, such as PDE5 inhibitors (see POST-MARKETING EXPERIENCE/Special Senses).
This medicine can help many men when it is used as prescribed by their doctors.
One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted.
This includes prescription and nonprescription medicines or remedies: Remember, Viagra should never be used with medicines that contain nitrates (see Viagra Is Not for Everyone).
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The usual dose is 50 milligrams.
Pregnancy, Nursing Mothers and Pediatric Use Viagra is not indicated for use in newborns, children, or women.
Therefore, treatments for erectile dysfunction, including Viagra, should not be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status.
If you become pregnant, contact your doctor.
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Physicians should also discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye, including whether such individuals could be adversely affected by use of vasodilators, such as PDE5 inhibitors (see POST-MARKETING EXPERIENCE/Special Senses).
Your doctor should determine if your heart is healthy enough to handle the extra strain of having sex.
Ritonavir greatly increased the systemic level of sildenafil in a study of healthy, non-HIV infected volunteers (11-fold increase in AUC, see Drug Interactions.
The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.
The mean subject age was 66.
After patients have taken Viagra, it is unknown when nitrates, if necessary, can be safely administered.
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Viagra may rarely cause a prolonged, painful erection.
You could get dizzy or faint.
The mean subject age was 66.
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Counseling of patients about the protective measures necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), may be considered.
Older adults—Elderly people are especially sensitive to the effects of sildenafil, which may increase their chance of having side effects.
The penis cannot fill with enough blood.
If this is not treated right away, it could lead to permanent sexual problems such as impotence.
Taking Viagra approximately 1 hour before sexual activity works best for most men.
Use Viagra with caution in the ELDERLY; they may be more sensitive to its effects.
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Taking Viagra with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke, or heart attack.
Viagra must never be used by men who are taking medicines that contain nitrates of any kind, at any time.
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FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby.
Others were reported to have occurred hours to days after the use of Viagra and sexual activity.
Contact your doctor or seek medical attention right away if you experience these symptoms.
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Most important fact about Viagra Viagra causes erections only during sexual excitement.
These effects on the metabolite are not expected to be of clinical consequence.
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Mothers who are taking this medicine for pulmonary arterial hypertension and who wish to breast-feed should discuss this with their doctor.
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The following information includes only the average doses of sildenafil.
It is not clear whether Viagra is the actual cause of vision loss.
This medicine can help many men when it is used as prescribed by their doctors.
Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.
Some conditions and medicines interfere with this natural erection process.
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Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse.
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You may report side effects to FDA at 1-800-FDA-1088.
Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) sildenafil and its active N-desmethyl metabolite were 45% and 57%, respectively.
Viagra may cause dizziness, drowsiness, fainting, or blurred vision.
Take it only before sexual activity.
In fixed-dose studies, the incidence of some adverse events increased with dose.
Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia.
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Figure 3 shows that regardless of the baseline levels of function, subsequent function in patients treated with Viagra was better than that seen in patients treated with placebo.
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The changes from baseline in scoring on the two end point questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) were highly statistically significantly in favor of Viagra.
You will need to discuss the benefits and risks of using Viagra while you are pregnant.
Viagra is not for regular use.
After sex is over, the erection goes away.
Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra.
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The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child Pugh class C) have not been studied.
Two of these subjects had a standing SBP < 85mmHg.
It does not contain all information about Viagra .