The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Viagra is not a hormone or an aphrodisiac.
Before taking Viagra, tell your doctor if you are allergic to any drugs, or if you have If you have any of these conditions, you may need a dose adjustment or special tests to safely take Viagra.
The usual dose is 50 milligrams.
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Tell your doctor about all the prescription and over-the-counter medications you use.
Store at room temperature Side effects cannot be anticipated.
Others were reported to have occurred hours to days after the use of Viagra and sexual activity.
Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes.
In a study of healthy male volunteers, sildenafil (100 mg) did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates.
Precautions While Using This Medicine Sildenafil has not been studied with other medicines used for treatment of erectile dysfunction.
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Viagra (50 mg) did not potentiate the hypotensive effect of alcohol in healthy volunteers with mean maximum blood alcohol levels of 0.
Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted.
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The usual dose is 50 milligrams.
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Viagra is not a hormone or an aphrodisiac.
Continue to take it as directed by your doctor.
Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg.
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Ritonavir greatly increased the systemic level of sildenafil in a study of healthy, non-HIV infected volunteers (11-fold increase in AUC, see Drug Interactions.
Viagra demonstrated statistically significant improvement compared to placebo in all 21 studies.
There is no controlled clinical data on the safety or efficacy of Viagra in the following groups; if prescribed, this should be done with caution.
In rare instances, men have reported an erection that lasts many hours.
In the rat pre- and postnatal development study, the no observed adverse effect dose was 30 mg/kg/day given for 36 days.
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Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11).
This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see Pharmacodynamics).
Twenty-five subjects were screened.
To avoid low blood pressure, do not take the 50-milligram or 100-milligram dose of Viagra within 4 hours of taking an alpha-blocking drug such as Cardura.
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Following at least 14 consecutive daily doses of doxazosin, Viagra 100 mg or matching placebo was administered simultaneously with doxazosin.
At the end of the long-term study, 88% of patients reported that Viagra improved their erections.
Viagra was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover).
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Viagra is not a hormone or an aphrodisiac.
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Mothers who are taking this medicine for pulmonary arterial hypertension and who wish to breast-feed should discuss this with their doctor.
If needed, your doctor may increase your daily dose to 100 mg or decrease your daily dose to 25 mg.
An erection will not occur just by taking a pill.
Seek emergency medical attention if you think you have used too much of this medicine.
Warnings There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease.
NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
It does not work in the absence of arousal.
One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted.
Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy.
If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately.
To decrease the chance of adverse events in patients taking ritonavir, a decrease in sildenafil dosage is recommended (see Drug Interactions, ADVERSE REACTIONS and DOSAGE AND ADMINISTRATION).
Use Viagra with caution in the ELDERLY; they may be more sensitive to its effects.
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4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 20% on placebo.
Viagra improved these aspects of sexual function: frequency, firmness and maintenance of erections; frequency of orgasm; frequency and level of desire; frequency, satisfaction and enjoyment of intercourse; and overall relationship satisfaction.
In some patients, concomitant use of these two drug classes can lower blood pressure significantly (see Drug Interactions) leading to symptomatic hypotension (e.
If Viagra gives you an allergic reaction, do not use it again.
It is not possible to determine whether these events are related directly to Viagra, to sexual activity, to the patient's underlying cardiovascular disease, to a combination of these factors, or to other factors (see WARNINGS for further important cardiovascular information).
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
You could get dizzy, faint, or even have a heart attack or stroke.
PREGNANCY and BREAST-FEEDING: Viagra is not approved for use in women.
All three were taking Viagra 100 mg, and all three reported mild adverse events at the time of reductions in standing SBP, including vasodilation and lightheadedness.
Continue to take it as directed by your doctor.
Permanent damage and impotence could result.
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After sex is over, the erection goes away.
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Following a review of the data from these first 4 subjects (details provided below), the Viagra dose was reduced to 25 mg.
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Doses range from 25 milligrams to 100 milligrams, depending on the drug's effect.
6 times the MRHD on a mg/m2 basis.
Of the four subjects who received Viagra 100 mg in the first part of this study, a severe adverse event related to blood pressure effect was reported in one patient (postural hypotension that began 35 minutes after dosing with Viagra with symptoms lasting for 8 hours), and mild adverse events potentially related to blood pressure effects were reported in two others (dizziness, headache and fatigue at 1 hour after dosing; and dizziness, lightheadedness and nausea at 4 hours after dosing).
The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo.
In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.
Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.
Taking Viagra with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke, or heart attack.
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To avoid low blood pressure, do not take the 50-milligram or 100-milligram dose of Viagra within 4 hours of taking an alpha-blocking drug such as Cardura.
Overdosage In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates and severities were increased.
Tell your doctor about all the prescription and over-the-counter medications you use.
If you do not get the results you expect, talk with your doctor.
Viagra should not be taken more than once a day.
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Do not use other medicines or treatments for ED while you are taking Viagra .
Stop using Viagra and get emergency medical help if you have sudden vision loss.
If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time.
Store at room temperature Side effects cannot be anticipated.
Sildenafil doses above 25 mg should not be taken within 4 hours of taking an alpha-blocker medicine.
Seek emergency medical attention if you think you have used too much of this medicine.
If you take Viagra with any nitrate medicine or recreational drug containing nitrates, your blood pressure could suddenly drop to an unsafe level.
Some of these side effects are more likely to occur with higher doses.
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Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil.
If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control.
There were no reports of syncope among these patients.
Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg.
Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including Viagra.
Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively.
Tell your doctor about any medicines you are taking.