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Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
If you are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are, ask your doctor or pharmacist.
Viagra was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years.
However, check with your doctor if any of the following side effects continue or are bothersome: More common Aches or pains in muscles; bloody nose; diarrhea; difficult or labored breathing; flushing; headache; nasal congestion; pain or tenderness around eyes and cheekbones; redness of skin; sneezing; stomach discomfort following meals; stuffy or runny nose; trouble in sleeping; unusually warm skin Rare Anxiety Note: The following rare side effects have not been completely established as being caused by sildenafil Abdominal pain; abnormal dreams; clumsiness or unsteadiness; cough; diarrhea or stomach cramps (severe or continuing); difficulty in swallowing; ear pain; increased amount of saliva; increased skin sensitivity; lack of coordination; loss of bladder control; mental depression; nausea; numbness or tingling of hands, legs, or feet; rectal bleeding; redness or irritation of the tongue; redness, soreness, swelling, or bleeding of gums; ringing or buzzing in ears; sensation of motion, usually whirling, ei
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An erection will not occur just by taking a pill.
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Do not keep outdated medicine or medicine no longer needed.
These patients had erectile dysfunction at baseline that was characterized by median categorical scores of 2 (a few times) on principal IIEF questions.
By controlling the enzyme phosphodiesterase, sildenafil helps to maintain an erection that is produced when the penis is stroked.
After patients have taken Viagra, it is unknown when nitrates, if necessary, can be safely administered.
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There was one subject with a decrease from baseline in standing systolic BP >30mmHg following Viagra 50 mg and one subject with a decrease from baseline in standing systolic BP > 30 mmHg following both Viagra 50 mg and placebo.
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Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.
If you take Viagra after a high-fat meal (such as a cheeseburger and french fries), the medicine may take a little longer to start working.
It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these.
If this is not treated right away, it could lead to permanent sexual problems such as impotence.
Metabolism and Excretion Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes.
Carcinogenesis, Mutagenesis, Impairment of Fertility Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29- and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg.
Combining Viagra with these drugs can cause a severe drop in blood pressure.
In another study in healthy male volunteers, coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Viagra (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil Cmax and a 1000% (11-fold) increase in sildenafil plasma AUC.
Following a review of the data from these first 4 subjects (details provided below), the Viagra dose was reduced to 25 mg.
Do not start using a new medication without telling your doctor.
A prolonged erection (priapism) can damage the penis.
Use protective measures and ask your doctor if you have any questions about this.
In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization.
In the first study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 2-period crossover design to 4 generally healthy males with benign prostatic hyperplasia (BPH).
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Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively.
When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29%.
Viagra is not a hormone or an aphrodisiac.
Check the label on the medicine for exact dosing instructions.
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Taking Viagra approximately 1 hour before sexual activity works best for most men.
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At 24 hours the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone.
Take Viagra exactly as it was prescribed for you.
Viagra must be used only under a doctor's supervision.
Although not all of these side effects may occur, if they do occur they may need medical attention.
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Concomitant administration of Viagra and an alpha-blocker may lead to symptomatic hypotension in some patients.
If you become pregnant, contact your doctor.
If you have questions about side effects, contact your health care provider.
These effects may be worse if you take it with alcohol or certain medicines.
If you have any questions about Viagra , please talk with your doctor, pharmacist, or other health care provider.
The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.
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In rare instances, men have reported an erection that lasts many hours.
Some conditions and medicines interfere with this natural erection process.
Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including Viagra.
Stop using Viagra and get emergency medical help if you have sudden vision loss.
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Viagra is a phosphodiesterase inhibitor.
Patients who are taking this medicine for pulmonary arterial hypertension may also need to be started at a lower dose.
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The manufacturer recommends a maximum of 1 dose per day (1 dose every 2 days for those taking ritonavir).
When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29%.
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Twenty subjects received Viagra 50 mg, but only 19 subjects received matching placebo.
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Therefore, age >65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil.
In another study in healthy male volunteers, coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Viagra (100 mg single dose) resulted in a 300% (4-fold) increase in sildenafil Cmax and a 1000% (11-fold) increase in sildenafil plasma AUC.
Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects.
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Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers.
At the same time, on-treatment function was better in treated patients who were less impaired at baseline.
On a global improvement question, 83% of patients reported improved erections on Viagra versus 12% on placebo.
Do not store in the bathroom.
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Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers").