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Contact your doctor right away if you have an erection that lasts more than 4 hours.
There were no reports of syncope among these patients.
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Overdose symptoms may include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.
Do not take more of Viagra than recommended or take it more often than once daily, or as directed by your doctor.
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It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors.
Depending on how and when the drug works for you, an interval of one-half hour to as much as 4 hours may prove ideal.
In vivo studies Three double-blind, placebo-controlled, randomized, two-way crossover studies were conducted to assess the interaction of Viagra with doxazosin, an alpha-adrenergic blocking agent.
Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects.
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An extra patient leaflet is available with Viagra .
It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil.
If not treated right away, permanent damage to your penis could occur (see How Sex Affects the Body).
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The use of Viagra offers no protection against sexually transmitted diseases.
Side effects may include: Abnormal vision (color tinge, blurring, sensitivity to light), acid indigestion, diarrhea, flushing, headache, nasal congestion, urinary tract infection Heart attack, stroke, heart irregularities, dangerous surges in blood pressure, and sudden death have all been reported after use of Viagra, usually in men with existing cardiac risk factors, and typically during or shortly after sex.
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Viagra was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated.
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Breast-feeding—It is not known whether sildenafil passes into breast milk.
Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects.
It is not known if Viagra is found in breast milk.
Keep the medicine from freezing.
If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result.
In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.
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If you are taking medicines called alpha-blockers for the treatment of high blood pressure or prostate problems, your blood pressure could suddenly drop.
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This helps you to achieve and maintain an erection.
It may also be used for other conditions as determined by your doctor.
Make sure you tell your doctor if you have any other medical problems, especially: Age greater than 50 years or Coronary artery disease or Diabetes or Hyperlipidemia (excess of lipids in the blood) or Hypertension (high blood pressure) or Low cup to disc ratio (“crowded disc”) or Smoking—These conditions may increase risk for a serious eye problem called NAION.
Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.
Consideration should be given to the following: - Patients should be stable on alpha-blocker therapy prior to initiating a PDE5 inhibitor.
Twenty subjects received Viagra 50 mg, but only 19 subjects received matching placebo.
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The dose may be increased by a doctor as needed and tolerated.
The mean subject age in this study was 66.
It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient's underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors (see PRECAUTIONS/Information for Patients).
This has occurred in a small number of people taking Viagra, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.
For oral dosage form (tablets): o For treatment of erectile dysfunction: + Adults up to 65 years of age—50 mg as a single dose no more than once a day, 1 hour before sexual intercourse.
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This includes nitroglycerin.
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Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra.
Viagra®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
For sildenafil, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to sildenafil.
Pharmacokinetics in Special Populations Geriatrics Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy younger volunteers (18–45 years).
Use it cautiously—if at all—if you've had a heart attack, stroke, or life-threatening heart irregularities within the past 6 months.
Outliers were defined as subjects with a standing systolic blood pressure of <85 mmHg or a decrease from baseline in standing systolic blood pressure of >30 mmHg at one or more timepoints.
It is not known if sildenafil passes into breast milk or if it could harm a nursing baby.
Physicians should advise patients of the potential for Viagra to augment the blood pressure lowering effect of alpha-blockers and anti-hypertensive medications.
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Others were reported to have occurred hours to days after the use of Viagra and sexual activity.
The primary endpoint was time to limiting angina in the evaluable cohort.
Do not use other medicines or treatments for ED while you are taking Viagra .
The mean subject age was 66.
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Drug information contained herein may be time sensitive.
No overdose of Viagra has been reported.
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If you have heart problems severe enough to make sexual activity a danger, you should avoid using Viagra.
Do not drive or perform other possibly unsafe tasks until you know how you react to it.
It is important to tell your doctor about any heart problems you may have now or may have had in the past.
No overdose of Viagra has been reported.
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Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
Most important fact about Viagra Viagra causes erections only during sexual excitement.
When vasodilators are used in combination, an additive effect on blood pressure may be anticipated.
If you have any questions about Viagra , please talk with your doctor, pharmacist, or other health care provider.
Heat or moisture may cause the medicine to break down.
This medicine usually begins to work within 30 minutes after taking it for erectile dysfunction.
Take it only before sexual activity.
Viagra should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia).
Do not start using a new medication without telling your doctor.
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Tell your doctor about all the prescription and over-the-counter medications you use.
Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels.
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In the third study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 3-period crossover design to 20 generally healthy males with BPH.
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Thereafter, Viagra 100mg or matching placebo was administered simultaneously with doxazosin 4 mg (14 subjects) or doxazosin 8 mg (6 subjects) in standard crossover fashion.
Physicians should advise patients of the potential for Viagra to augment the blood pressure lowering effect of alpha-blockers and anti-hypertensive medications.
Physicians should also discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye, including whether such individuals could be adversely affected by use of vasodilators, such as PDE5 inhibitors (see POST-MARKETING EXPERIENCE/Special Senses).
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No overdose of Viagra has been reported.
Mean sildenafil plasma concentrations measured after the administration of a single oral dose of 100 mg to healthy male volunteers is depicted below: Figure 1: Mean Sildenafil Plasma Concentrations in Healthy Male Volunteers.
This has occurred in a small number of people taking Viagra, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.
Of the four subjects who received Viagra 100 mg in the first part of this study, a severe adverse event related to blood pressure effect was reported in one patient (postural hypotension that began 35 minutes after dosing with Viagra with symptoms lasting for 8 hours), and mild adverse events potentially related to blood pressure effects were reported in two others (dizziness, headache and fatigue at 1 hour after dosing; and dizziness, lightheadedness and nausea at 4 hours after dosing).
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Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased.
For example: If you are older than age 65, or have serious liver or kidney problems, your doctor may start you at the lowest dose (25 mg) of Viagra.
It can help many men who have erectile dysfunction get and keep an erection when they become sexually excited (stimulated).
Geriatric Use Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil (see CLINICAL PHARMACOLOGY: Pharmacokinetics in Special Populations).