Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury.
Physicians should advise patients to stop taking PDE5 inhibitors, including Viagra, and seek prompt medical attention in the event of sudden decrease or loss of hearing.
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These doses represent, respectively, about 20 and 40 times the MRHD on a mg/m2 basis in a 50 kg subject.
Tell your doctor about all the prescription and over-the-counter medications you use.
In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 1 hour after administration of Viagra 50 mg and resolving after approximately 7.
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Patients on multiple antihypertensive medications were included in the pivotal clinical trials for Viagra.
Sildenafil doses above 25 mg should not be taken within 4 hours of taking an alpha-blocker medicine.
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours.
There were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study.
Absorption and Distribution Viagra is rapidly absorbed.
If not treated right away, permanent damage to your penis could occur (see How Sex Affects the Body).
If you become pregnant, contact your doctor.
After the man is done having sex, this extra blood flows out of the penis back into the body.
Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia.
Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
Do not take more of Viagra than recommended or take it more often than once daily, or as directed by your doctor.
Pregnancy—Sildenafil is not indicated for use in women.
Sildenafil is not indicated for use in women for erectile dysfunction.
If you have a condition that might result in long-lasting erections, such as sickle cell anemia, multiple myeloma (a disease of the bone marrow), or leukemia, use Viagra with caution.
There was no impairment of fertility in rats given sildenafil up to 60 mg/kg/day for 36 days to females and 102 days to males, a dose producing an AUC value of more than 25 times the human male AUC.
Analysis of the safety database showed no apparent difference in the side effect profile in patients taking Viagra with and without antihypertensive medication.
If you do not get the results you expect, talk with your doctor.
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Call your doctor for medical advice about side effects.
Before taking Viagra, tell your doctor about all other medications you use for erectile dysfunction, or if you are using any of the following medications: an antibiotic such as clarithromycin (Biaxin), clotrimazole (Mycelex Troche), dalfopristin/quinupristin (Synercid), erythromycin (E.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
After the man is done having sex, this extra blood flows out of the penis back into the body.
Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Viagra.
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Do not take extra medicine to make up the missed dose.
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Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse.
Viagra is a pill used to treat erectile dysfunction (impotence) in men.
Do not start or stop taking any medicines before checking with your doctor or pharmacist.
Follow your doctor's instructions.
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Tell your health care provider if you are taking any other medicines, especially any of the following: Alpha-blockers (eg, doxazosin), amlodipine, medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), fluvoxamine, H2 antagonists (eg, cimetidine, famotidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra 's side effects Bosentan or rifampin because they may decrease Viagra 's effectiveness This may not be a complete list of all interactions that may occur.
If you are taking a protease inhibitor, your dose may be adjusted (please see Finding the Right Dose for You).
Do not take more of Viagra than recommended or take it more often than once daily, or as directed by your doctor.
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Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity.
How should you take Viagra?
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When Viagra was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials, the following adverse events were reported: Other adverse reactions occurred at a rate of >2%, but equally common on placebo: respiratory tract infection, back pain, flu syndrome, and arthralgia.
Viagra is only for patients with erectile dysfunction.
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It is not known if sildenafil passes into breast milk or if it could harm a nursing baby.
The pattern of responses was similar for the other principal question, the ability to achieve an erection sufficient for intercourse.
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eatments that cause erections (eg, medicines injected or inserted into the penis, implants or vacuum pumps) Some MEDICINES MAY INTERACT with Viagra .
If you suspect an overdose, seek medical attention immediately.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.
If you are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are, ask your doctor or pharmacist.
FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby.
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If you have a condition that might result in long-lasting erections, such as sickle cell anemia, multiple myeloma (a disease of the bone marrow), or leukemia, use Viagra with caution.
This patient had been taking minoxidil, a potent vasodilator, during the study.
The usual dose is 50 milligrams.
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When Viagra was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials, the following adverse events were reported: Other adverse reactions occurred at a rate of >2%, but equally common on placebo: respiratory tract infection, back pain, flu syndrome, and arthralgia.
Adverse Reactions CLINICAL TRIALS Viagra was administered to over 3700 patients (aged 19–87 years) during pre-marketing clinical trials worldwide.
Viagra must never be used by men who are taking medicines that contain nitrates of any kind, at any time.
You will need to have a thorough medical exam to diagnose your erectile dysfunction and to find out if you can safely take Viagra alone or with your other medicines.
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If you need emergency medical care for a heart problem, it is important that your healthcare provider knows when you last took sildenafil.
4 on placebo; similarly, group mean success rates (total successes divided by total attempts) were about 66% on Viagra vs about 20% on placebo.
Viagra may rarely cause a prolonged, painful erection.
Take Viagra exactly as it was prescribed for you.
Side effects may include: Abnormal vision (color tinge, blurring, sensitivity to light), acid indigestion, diarrhea, flushing, headache, nasal congestion, urinary tract infection Heart attack, stroke, heart irregularities, dangerous surges in blood pressure, and sudden death have all been reported after use of Viagra, usually in men with existing cardiac risk factors, and typically during or shortly after sex.
It is not possible to determine whether these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, or to a combination of these.
Warnings There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease.
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You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours.
chills; sudden weakness; swelling of face, hands, feet, or lower legs; twitching of muscles; unusual tiredness or weakness; unusual feeling of burning or stinging of skin Incidence not known Blindness Other side effects may occur that usually do not need medical attention.
Store at room temperature Side effects cannot be anticipated.
In dose period 1, subjects were administered open-label doxazosin and a single dose of Viagra 50 mg simultaneously, after at least 14 consecutive days of doxazosin.
This is consistent with ritonavir's marked effects on a broad range of P450 substrates.
The safety of Viagra is unknown in patients with bleeding disorders and patients with active peptic ulceration.